PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION

SCREENING OF PATIENTS WITH UNSPECIFIED ACUTE HEPATITIS AND REVIEW OF THE LITERATURE

Authors

  • Daniel Ivanov Sofia University “St. Kliment Ohridski” Author
  • TenchoTenev, MD National Centre of Infectious and Parasitic Diseases Author
  • Assistant Professor Elica Golkocheva-Markova,PhD National Centre of Infectious and Parasitic Diseases Author

DOI:

https://doi.org/10.58395/pipd.v48i1.31

Keywords:

HBV, anti-HBc, acute hepatitis

Abstract

Background. Among the various serological markers employed in the hepatitis B virus (HBV) differential laboratory diagnosis, serum HBsAg is considered the most reliable. In order to characterise the HBV infection, another important diagnostic marker is employed – the HBc antibody (anti-HBc). There are three categories of anti-HBc-positive individuals: patients with HBV immunity, patients with chronic HBV and individuals with the so-called isolated anti-HBc pattern. The current study aimed to evaluate the presence of anti-HBc in patients negative for HBsAg whose clinical diagnosis was acute viral hepatitis.

Material and methods. A total of 88 specimens were examined, of which 75 sera were from prospective patients diagnosed with acute viral hepatitis, and 13 sera from breast milk donors. Antibodies against the hepatitis B core antigen were detected by enzyme-linked immunosorbent assay (ELISA).

Results. Twenty-eight (32%) of all tested samples were positive for anti-HBc. Nineteen samples belonged to male and 9 to female patients. One positive sample was from a breast milk donor. Two age groups, namely 46-55 years and 56-65 years, demonstrated the highest rate of anti-HBc positivity. Among the other age groups positivity rates varied from 15% to 36%. The results demonstrated a linear trend of increasing anti-HBc prevalence with increasing age.

Conclusions. Considering the highest rate of anti-HBc positivity being demonstrated in the age range 46-65 years, it could be assumed that a sufficient number of risk factors accumulate over time resulting in greater population susceptibility to HBV infection.

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Author Biographies

  • TenchoTenev, MD, National Centre of Infectious and Parasitic Diseases

    National Reference Laboratory “Hepatitis viruses”, Department of Virology

  • Assistant Professor Elica Golkocheva-Markova,PhD, National Centre of Infectious and Parasitic Diseases

    National Reference Laboratory “Hepatitis viruses”, Department of Virology

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Published

2020-05-12 — Updated on 2020-05-13

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How to Cite

(1)
Ivanov, D.; Tenev, T.; Golkocheva-Markova, E. PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION: SCREENING OF PATIENTS WITH UNSPECIFIED ACUTE HEPATITIS AND REVIEW OF THE LITERATURE. Probl Infect Parasit Dis 2020, 48 (1), 33-38. https://doi.org/10.58395/pipd.v48i1.31.

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