STUDIES ON THE EPIDEMIOLOGICAL AND MOLECULAR CHARACTERISTICS OF THE HEPATITIS E VIRUS IN BULGARIA: A COMPREHENSIVE REVIEW
DOI:
https://doi.org/10.58395/pipd.v49i3.75Keywords:
Hepatitis E virus, prevalence, haemodialysis patients, domestic pigsAbstract
Hepatitis E virus (HEV) is a RNA virus that belongs to the family Hepeviridae. The virus causes self-limited acute hepatitis in immunocompetent individuals, but can become chronic or present with extrahepatic manifestations in immunosuppressed patients. In recent years, due to the increased scientific interest in HEV infection, the number of laboratory-confirmed cases have also increased. The first study of HEV infection in Bulgaria was carried out in mid-90s of the last century by Teoharov et al. Ten years later, more in-depth studies of HEV infection began. The main focus was on the evaluation of HEV seroprevalence among different target populations. Attention was also paid to the zoonotic potential of the infection. The aim of the present review is to summarize studies on HEV conducted by Bulgarian authors in regards to HEV seroprevalence among humans and animals, clinical and epidemiological characteristics of HEV infection, and molecular-characteristics of HEV.
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References
Himmelsbach K, Bender D, Hildt E. Life cycle and morphogenesis of the hepatitis E virus, Emerging Microbes & Infections. 2018; 7 (1): 1-12.
Kelly A, Netzler N, White PA. Ancient recombination events and the origins of hepatitis E virus. BMC evolutionary biology. 2016; 16 (1): 210.
Purdy MA, Harrison TJ, Jameel S, Meng XJ, Okamoto H, Van der Poel W, Smith DB. ICTV Virus Taxonomy Profile: Hepeviridae. Journal General Virology. 2017; 98 (11): 2645–2646.
Hepatitis E. World Health Organization. [Online] July 27, 2020. https://www.who.int/news-room/fact-sheets/detail/hepatitis-e. (available on 17.02.2021).
Lhomme S, Marion O, Abravanel F, Izopet J, Kamar N. Clinical Manifestations, Pathogenesis and Treatment of Hepatitis E Virus Infections. J Clin Med. 2020;9 (2): 331.
Balayan MS, Andjaparidze AG, Savinskaya SS, Ketiladze ES, Braginsky DM, Savinov AP, Poleschuk VF. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology. 1983; 20 (1): 23-31.
Teoharov P, Tiholova M, Draganov P, Lilyanova V, Ivanova R, Varleva T, et al. First cases of hepatitis E virus infection in Bulgaria. Infectologia. 1995; 32 (3): 17–18. [in Bulgarian]
Teoharov P, Pishmisheva M, Kovaleva. Hepatitis E virus infection: a case report. Infectologia. 2008; 45(1):43–44 [in Bulgarian].
Teoharov P., E. Markova, T. Cherveniakova, G. Goranova, A. Andonov. 11 National Congess of Clinical Microbiology and Infections, Sofia, 09–11 May, 2013 9
Baymakova M, Sakem B, Plochev K, Popov GT, Mihaylova-Garnizova R, Kovaleva V, Kundurdjiev T. Epidemiological characteristics and clinical manifestations of hepatitis E virus infection in Bulgaria: A report on 20 patients. Srp Arh Celok Lek. 2016; 144 (1-2): 63-68.
Stoykova Zh, Ivanova L,Tsaneva-Damyanova D, Kostadinova Ts. Hepatitis E virus infection in Northeastern Bulgaria. Medical Review. 2017; 53 (3): 30-34. [in Bulgarian]
Teoharov P, Kevorkyan A, Raycheva R, Golkocheva-Markova E, Trandeva-Bankova D, Andonov A. Data on the prevalence of hepatitis E virus in Bulgaria. C. R. Acad. Bulg. Sci. 2014; 67(10): 1427-1432.
Mladenova-Dimitrova Z, Gotseva A, Velcheva D. Prevalence of hepatitis E in general population in Bulgaria. Obshta meditsina. 2020;22 (3): 16-22. [in Bulgarian]
Baymakova M., Terzieva K., Popov, R., Grancharova E., Kundurzhiev T., Pepovich, R., Tsachev I. Seroprevalence of Hepatitis E Virus Infection among Blood Donors in Bulgaria. Viruses. 2021; 13(3): 492.
Purcell RH, Emerson SU. Hepatitis E: An emerging awareness of an old disease. Journal Hepatol. 2008; 48 (3): 494-503.
Sharifipour S, Davoodi Rad K. Seroprevalence of hepatitis E virus among different age groups in Tehran, Iran. New Microbes New Infect. 2019; 34: 100638.
Baha S, Behloul N, Liu Z, Wei W, Shi R, Meng J. Comprehensive analysis of genetic and evolutionary features of the hepatitis E virus. BMC Genomics. 2019; 20 (1): 790.
Smith DB, Izopet J, Nicot F, Simmonds P, Jameel S, Meng X-J, Norder H, Okamoto H, van der Poel WHM, Reuter G and Purdy MA. Update: proposed reference sequences for subtypes of hepatitis E virus (species Orthohepevirus A). J. Gen. Virol. 2020; 101: 692–698.
Bruni R, Villano U, Equestre M, Chionne P, Madonna E, Trandeva-Bankova D, Peleva-Pishmisheva M, Tenev T, Cella E, Ciccozzi M, Pisani G, Golkocheva-Markova E, Ciccaglione AR. Hepatitis E virus genotypes and subgenotypes causing acute hepatitis, Bulgaria, 2013-2015. PLoS One. 2018; 13 (6): e0198045.
Cella E, Golkocheva-Markova E, Sagnelli C, Scolamacchia V, Bruni R, Villano U, Ciccaglione AR, Equestre M, Sagnelli E, Angeletti S, Ciccozzi M. Human hepatitis E virus circulation in Bulgaria: Deep Bayesian phylogenetic analysis for viral spread control in the country. J Med Virol. 2019; 91(1): 132-138.
Ferri G, Vergara A. Hepatitis E virus in the food of animal origin: a review. Foodborne Pathog Dis. 2021; 18 (6): 368-377.
Pishmisheva M, Baymakova M, Golkocheva-Markova E, Kundurzhiev T, Pepovich R, Popov GT., Tsachev I. First serological study of hepatitis E virus infection in pigs in Bulgaria. C. R. Acad. Bulg. Sci. 2018; 71(7): 1001–1008.
Tsachev I, Baymakova M, Pepovich R., Palova N, Marutsov P, Gospodinova K, Kundurzhiev T, Ciccozzi M. High seroprevalence of hepatitis E virus infection among East Balkan Swine (Sus scrofa) in Bulgaria: preliminary results. Pathogens. 2020; 9 (11): 911.
Takova K, Koynarski T, Minkov I, Ivanova Z, Toneva V, Zahmanova G. Increasing Hepatitis E Virus Seroprevalence in Domestic Pigs and Wild Boar in Bulgaria. Animals (Basel). 2020; 10 (9): 1521.
European Association for the Study of the Liver. EASL Clinical Practice Guidelines on hepatitis E virus infection. J Hepatol. 2018; 68 (6): 1256-1271.
Pishmishesheva, M., Baymakova, M. Hepatitis E virus infection: underrated and unrecognized. Medical review. 2014; 50 (6): 5-12. [in Bulgarian]
Pishmisheva M, Teoharov P. Hepatitis viralis E – clinical manifestationes – case-report. Nauka infektol. parazitol. 2012; 3 (2): 13-15. [in Bulgarian]
Golkocheva-Markova E, Pishmisheva-Peleva M, Trandeva-Bankova D, Tenev T, Teoharov P. Serological Investigation in hepatitis E virus infection. Nauka Infectologia Parazitologia., 2017; 1 (14):17-20. [in Bulgarian]
Popov G, Gotseva A. Acute hepatic failure due to viral hepatitis E. Voenna meditsina. 2019; 71 (3): 82-85. [in Bulgarian]
Pishmisheva M, Golkotcheva-Markova E, Naseva E, Argirova R. Thrombocytopenia in Hepatitis E. Nauka infektol. parazitol. 2018; 9 (1): 49-52. [in Bulgarian]
Pishmisheva M, Golkotcheva-Markova E, Argirova R, Murdjeva M, Stoycheva M. Acute hepatitis E virus infection with cholestasis syndrome lasting more than six months. Nauka infektol. parazitol. 2017; 8 (1): 22-26. [in Bulgarian]
Pishmisheva-Peleva M; Golkotcheva-Markova E; Karamisheva M; Ivanov I; Velkova D; Argirova R; Stoycheva M. Haemophagocytic Syndrome in Acute Hepatitis E Virus infection – a Clinical Case. Nauka infektol. parazitol. 2020; 11 (1): 23-26. [in Bulgarian]
Kumar N, Sarin SK. Hepatitis E- Is it a risk to transfusion safety? Asian J Transfus Sci. 2013; 7 (1): 1-3.
Pishmisheva M, Shikov P, Golkocheva-Markova Е, Kotsev S, Naseva E, Vatev N, Argirova R. Spread of Hepatitis E Viral Infection among Hemodialysis Patients in Pazardzhik District, Bulgaria. Int J Curr Microbiol Appl Sci. 2020; 9(1): 1086-1092.
Atanasova M, Komitova R, Kevorkyan A, Raycheva R, Golkocheva-Markova E, Tenev T, Tzochev G, Pavlova R. Hepatitis among hemodialysis patients from a single center in Plovdiv. Nephrol. Dial. Transplant. 2020; 26, 56–64. [in Bulgarian]
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Copyright (c) 2022 Elitsa Golkocheva-Markova, Chiydem Ismailova, Tencho Tencho Tenev, Lubomira Nikolaeva-Glomb (Author)
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