UNEXPECTEDLY HIGH NUMBER OF WEST NILE NEUROINVASIVE DISEASES IN BULGARIA IN 2018

Authors

  • Prof. Iva Christova, MD, PhD, DSc National Centre of Infectious and Parasitic Diseases
  • Assist. Prof. Elitsa Panayotova, PhD National Centre of Infectious and Parasitic Diseases
  • Assist. Prof. Iva Trifonova, PhD National Centre of Infectious and Parasitic Diseases
  • Evgenia Taseva, PhD National Centre of Infectious and Parasitic Diseases
  • Assist. Prof. Teodora Gladnishka, PhD National Centre of Infectious and Parasitic Diseases

Keywords:

viral encephalitis, flavivirus, Bulgaria, West Nile virus

Abstract

West Nile virus (WNV) is an emerging arbovirus in Europe and America which disseminated widely in recent years. This study analysed epidemiological data and laboratory findings of probable and confirmed human WNV cases in Bulgaria in 2018. A total of 15 patients with WNV
infection were detected in 2018, with 2 deaths among them. All patients were diagnosed in August or September. Four patients were from Sofia district, 4 from Burgas, 3 from Plovdiv and 1 from each of the following districts: Shumen, Yambol and Pazardzhik. Laboratory diagnosis for 7 of the patients was based solely on detection of specific antibodies in the serum samples. Eight patients met the criteria for confirmed WNV case. In 6 of them WNV genome was detected by RT-PCR in blood or urine sample and in 3 patients specific IgM antibodies were found in CSF samples which confirmed WNV neuroinvasive infection. The high number of diagnosed human WNV cases in 2018 in Bulgaria is a good sign of increasing recognition of the disease. More efforts are needed in proper transportation of clinical samples undergoing genetic detection of the viral genome. WNV neuroinvasive infection should be suspected and included in the differential diagnosis of viral encephalitis or meningoencephalitis especially in late summer and early autumn.

Author Biographies

Prof. Iva Christova, MD, PhD, DSc, National Centre of Infectious and Parasitic Diseases

Deputy Director

Assist. Prof. Elitsa Panayotova, PhD, National Centre of Infectious and Parasitic Diseases

Head of NRL Vector-borne infections, listeria and leptospires 

Department of Microbiology

Assist. Prof. Iva Trifonova, PhD, National Centre of Infectious and Parasitic Diseases

NRL of Vector-borne infections, listeria and leptospires 

Evgenia Taseva, PhD, National Centre of Infectious and Parasitic Diseases

NRL of Vector-borne infections, listeria and leptospires

Assist. Prof. Teodora Gladnishka, PhD, National Centre of Infectious and Parasitic Diseases

NRL of Vector-borne infections, listeria and leptospires 

References

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Published

2018-12-27

How to Cite

Christova, I., Panayotova, E., Trifonova, I., Taseva, E., & Gladnishka, T. (2018). UNEXPECTEDLY HIGH NUMBER OF WEST NILE NEUROINVASIVE DISEASES IN BULGARIA IN 2018. PROBLEMS of Infectious and Parasitic Diseases, 46(2), 16-19. Retrieved from https://pipd.ncipd.org/index.php/pipd/article/view/46_2_3_UNEXPECTEDLY_HIGH_NUMBER_OF_WEST_NILE_NEUROINVASIVE_DISEA

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