• Eleonora Kaneva National Centre of Infectious and Parasitic Diseases Author https://orcid.org/0000-0003-3869-117X
  • Rumen Harizanov Author
  • Nina Tsvetkova Author
  • Iskren Kaftanjiev Author
  • Raina Borisova Author
  • Aleksandra Ivanova Author
  • Mihaela Videnova Author
  • Desislava Velcheva Author
  • Ivailo Alexiev Author
  • Reneta Dimitrova Author
  • Maria Pavlova Author
  • Ekaterina Aleksandrova Author




Enterobius vermicularis, molecular characterization, cox1 gene, intestinal imbalance


Enterobius vermicularis is an intestinal parasite with a cosmopolitan distribution and the disease which causes (enterobiasis) is one of the most common helminth infection worldwide. According to literature data it affects nearly 1 billion people and is found in various socio-economic groups. Everyone is susceptible to infection, but children are more often affected than adults due to their poorly developed hygiene habits. Patients with enterobiasis are often reinfected which together with the high endurance of the pinworm eggs in the environment contributes to the difficult control of the disease. In recent decades, a number of studies have been conducted on the genotypic characteristics of the nematode, including sequencing, which accumulates data on phylogenetic varieties of the species to improve the diagnosis and control of this infection in humans.
The available data reveal influence of E. vermicularis on the local immunity of intestinal mucosa in infected individuals, but these data are scarce and contradictory and do not clarify the significance of this influence on the clinical manifestations of the disease. Additional studies are needed to define the relationship of this effect with the clinical symptoms of the disease.


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Author Biography

  • Eleonora Kaneva, National Centre of Infectious and Parasitic Diseases

    Department of Parasitology and Tropical Medicine


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How to Cite

Kaneva, E.; Harizanov, R.; Tsvetkova, N.; Kaftanjiev, I.; Borisova, R.; Ivanova, A.; Videnova, M.; Velcheva, D.; Alexiev, I.; Dimitrova, R.; Pavlova, M.; Aleksandrova, E. E. VERMICULARIS – PROSPECTS FOR FUTURE RESEARCH: A BRIEF LITERATURE REVIEW. Probl Infect Parasit Dis 2023, 50 (2), 13-18. https://doi.org/10.58395/pipd.v50i2.92.

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